Increased Adrenergic Signaling Is Responsible for Decreased Glucose-Stimulated Insulin Secretion in the Chronically Hyperinsulinemic Ovine Fetus
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چکیده
منابع مشابه
Glucose-stimulated Cdc42 signaling is essential for the second phase of insulin secretion.
The small Rho family GTPases Cdc42 and Rac1 have each been shown to function in insulin exocytosis and are presumed to function in actin remodeling and insulin granule mobilization. However, whether either GTPase is required for the mobilization phase of insulin release (second phase) and are linked in a common signaling pathway has remained unknown. Here we demonstrate that small interfering R...
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ژورنال
عنوان ژورنال: Endocrinology
سال: 2015
ISSN: 0013-7227,1945-7170
DOI: 10.1210/en.2014-1393